Background: 

Subjective cognitive decline (SCD) may represent a low-burden indicator of dementia risk. The value of SCD as a proxy marker, however, depends on the consistency of associations between subjective and objective cognitive measures across sociodemographic and psychological factors.

Methods: 

We evaluated baseline data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study (n=1615). SCD was measured using the 12-item Everyday Cognition (ECog) scale. Using linear regression models with interaction terms, we evaluated 6 potential modifiers (age, sex, race/ethnicity, educational attainment, family history of dementia, and depressive symptoms) of the association between cognitive performance (episodic memory, executive function) and SCD.

Results: 

Lower episodic memory and executive function scores were associated with higher log(ECog scores) (more SCD). Older age and elevated depressive symptoms were associated with higher log(ECog scores). Age (interaction P=0.002) and education (interaction P=0.01) modified the association between executive function and log(ECog scores). Specifically, associations between executive function and log(ECog scores) were stronger among participants with more education and less pronounced among older participants.

Conclusions: 

The association between cognitive performance and log(ECog scores) differed little across sociodemographic and psychological factors. SCD as measured by the ECog may be a valuable proxy for cognitive performance in diverse older adults.

中文翻译：

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不同老年人群中认知测试表现与主观认知下降之间的关联：KHANDLE 研究的结果。

背景： 

主观认知能力下降（SCD）可能代表痴呆风险的低负担指标。然而，SCD 作为代理标记的价值取决于跨社会人口统计学和心理因素的主观和客观认知测量之间关联的一致性。

方法： 

我们评估了 Kaiser 健康老龄化和多样化生活经历 (KHANDLE) 研究 (n=1615) 的基线数据。SCD 使用 12 项日常认知 (ECog) 量表进行测量。使用具有交互项的线性回归模型，我们评估了认知表现（情景记忆、执行功能）与 SCD 之间关联的 6 个潜在修饰因素（年龄、性别、种族/民族、教育程度、痴呆家族史和抑郁症状）。

结果： 

较低的情景记忆和执行功能评分与较高的 log（ECog 评分）（更多的 SCD）相关。年龄较大和抑郁症状加重与较高的 log（ECog 评分）相关。年龄（交互作用P = 0.002）和教育程度（交互作用P = 0.01）改变了执行功能和日志（ECog 分数）之间的关联。具体来说，执行功能和日志（ECog 分数）之间的关联在受教育程度较高的参与者中更强，而在年龄较大的参与者中则不太明显。

结论： 

认知表现与日志（ECog 分数）之间的关联在社会人口统计学和心理因素方面几乎没有差异。ECog 测量的 SCD 可能是不同老年人认知能力的一个有价值的指标。