Heat shock protein 60 (HSP60) is a highly conserved protein abundantly expressed in both prokaryotic and eukaryotic cells. In mammals, HSP60 has been primarily considered to reside in the mitochondria, where HSP60 and HSP10 form a complex and facilitate mitochondrial protein folding. However, HSP60 is also observed in the cytoplasm, the plasma membrane, and the extracellular space. HSP60 regulates a broad spectrum of cellular events including protein trafficking, peptide hormone signaling, cell survival, cell proliferation, inflammation, and immunization. In the cardiovascular system, growing evidence indicates that HSP60 could not only play an important role under physiological conditions, but also regulate the initiation and progression of heart failure and atherosclerosis. In this review, we focus on recent progress in understanding the function of HSP60 in cardiomyocytes, endothelial cells, and vascular smooth muscle cells (VSMCs), respectively, and discuss the related signaling pathways that have been found in these cells, so as to illustrate the role of HSP60 in the development of cardiovascular disease.

中文翻译：

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热休克蛋白60在心血管生理和疾病中的作用。

热休克蛋白60（HSP60）是高度保守的蛋白，在原核和真核细胞中均大量表达。在哺乳动物中，HSP60主要被认为存在于线粒体中，在那里HSP60和HSP10形成复合物并促进线粒体蛋白折叠。但是，在细胞质，质膜和细胞外空间中也观察到HSP60。HSP60调节广泛的细胞事件，包括蛋白质运输，肽激素信号传导，细胞存活，细胞增殖，炎症和免疫。在心血管系统中，越来越多的证据表明HSP60不仅可以在生理条件下发挥重要作用，而且还可以调节心力衰竭和动脉粥样硬化的发生和发展。在这篇评论中