BackgroundBrain-derived neurotrophic factor (BDNF) is involved in neurogenesis and in the protection against oxidative damage and neuronal apoptosis. After exercise, there is an increased expression of this myokine, especially in skeletal muscle and brain. Low BDNF levels have been described in neurodegenerative diseases. Alcoholics show both muscle atrophy and brain atrophy. Thus, this study was performed in order to analyze serum BDNF levels among alcoholics and their associations with brain atrophy and muscle strength.MethodsSerum BDNF values were determined to 82 male alcoholics and 27 age-matched controls, and compared with handgrip strength, with the presence of brain atrophy, assessed by computed tomography, and with the intensity of alcoholism and liver function derangement.ResultsBDNF levels and handgrip strength were significantly lower among patients. Handgrip strength was correlated with BDNF values, both in the whole population and in alcoholics, especially in patients over 59 years of age. BDNF was poorly related to liver dysfunction but showed no relationship with brain atrophy or age.ConclusionChronic alcoholics show decreased BDNF serum levels that are related to muscle function impairment rather than to age, brain atrophy, liver dysfunction, or the amount of ethanol consumed.

中文翻译：

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酒精中毒患者的脑源性神经营养因子

背景脑源性神经营养因子 (BDNF) 参与神经发生和保护免受氧化损伤和神经元凋亡。运动后，这种肌动蛋白的表达增加，尤其是在骨骼肌和大脑中。已经在神经退行性疾病中描述了低 BDNF 水平。酗酒者表现出肌肉萎缩和脑萎缩。因此，本研究旨在分析酗酒者的血清 BDNF 水平及其与脑萎缩和肌肉力量的关系。脑萎缩，通过计算机断层扫描评估，酒精中毒和肝功能紊乱的强度。结果BDNF水平和握力在患者中显着降低。握力与 BDNF 值相关，无论是在整个人群中还是在酗酒者中，尤其是在 59 岁以上的患者中。BDNF与肝功能障碍的相关性较差，但与脑萎缩或年龄无关。结论慢性酗酒者显示BDNF血清水平降低与肌肉功能障碍有关，而不是与年龄、脑萎缩、肝功能障碍或乙醇消耗量有关。