Background: An increased expression of interleukin (IL)-15, a cytokine with a key role in stimulating innate and adaptive immune cells, such as dendritic cells (DC), natural killer cells, and T cells, has been observed in infectious and inflammatory diseases, including autoimmune diseases as well as cancer. Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a type 2 immune response. Objective: To explore the expression of IL-15 and its pattern in AD skin. Method: Immunofluorescence staining was performed on skin specimens of AD skin, nonlesional AD skin (AD NL), and normal skin (NS) using antibodies directed against IL-15 and CD3, mast cell tryptase, eosinophil cationic protein, CD68, CD11b, CD1a, and vimentin. Results: A significantly higher IL-15 expression in AD and AD NL was observed in both the epidermis (p = 0.0003) and the dermis (p = 0.0154) as compared to NS. Cells expressing IL-15 were mainly keratinocytes, CD1a⁺ DC, CD11b⁺ DC, CD68⁺ macrophages, and vimentin⁺ fibroblasts. In AD, an increase in the relative numbers of IL-15 expressing CD1a⁺ DC, macrophages, and fibroblasts was noted. Conclusion: Our results demonstrate an expression of IL-15 in AD similar to that of eosinophilic esophagitis which is also a type 2 disease. IL-15 may serve as a therapeutic target for AD.
Int Arch Allergy Immunol

中文翻译：

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特应性皮炎中的IL-15表达模式。

背景：白细胞介素（IL）-15的表达增加，这种细胞因子在刺激先天性和适应性免疫细胞（如树突状细胞（DC），自然杀伤细胞和T细胞）中起关键作用疾病，包括自身免疫性疾病以及癌症。特应性皮炎（AD）是一种常见的炎症性皮肤病，其特征在于2型免疫反应。目的：探讨IL-15在AD皮肤中的表达及其模式。方法：使用针对IL-15和CD3，肥大细胞类胰蛋白酶，嗜酸性粒细胞阳离子蛋白，CD68，CD11b，CD1a的抗体，对AD皮肤，非病变性AD皮肤（AD NL）和正常皮肤（NS）的皮肤样本进行免疫荧光染色。和波形蛋白。结果：与NS相比，在表皮（p = 0.0003）和真皮（p = 0.0154）中都观察到AD和AD NL中IL-15的表达明显升高。表达IL-15的细胞主要是角质形成细胞，CD1a ⁺ DC，CD11b ⁺ DC，CD68 ⁺巨噬细胞和波形蛋白⁺成纤维细胞。在AD中，注意到表达IL-15的CD1a ⁺ DC，巨噬细胞和成纤维细胞的相对数量增加。结论：我们的结果证明IL-15在AD中的表达与嗜酸性食管炎相似，后者也是2型疾病。IL-15可以作为AD的治疗靶标。
Int Arch过敏免疫