Full-thickness skin injury is a serious and intractable clinical problem. Wound dressing is urgently needed to treat serious skin defects or induce skin reconstruction. For the first time, we demonstrated a borosilicate bioglass (BBG)-incorporated sodium alginate (SA) wound dressing by a simple and effective technique for accelerated wound healing. The physical and chemical properties, in vitro and in vivo properties of SA-BBG composite wound dressing have been investigated. The results show that the SA-BBG composite dressing possesses good water absorption performance. The boron and silicon ions in BBG can maintain stable and sustained release. Most importantly, the SA-BBG composite wound dressing shows outstanding wound healing ability in full-thickness skin defects in rats. The wounds treated with SA-BBG composite dressing groups had almost closed at day 15. When the ratio of sodium alginate to bioglass in the sponge is 3:1, the wound healing effect is the best....

中文翻译：

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用于加速全层皮肤伤口愈合的硼硅酸盐-生物玻璃掺入海藻酸钠复合伤口敷料的制备和表征。

全层皮肤损伤是一个严重且棘手的临床问题。迫切需要伤口敷料来治疗严重的皮肤缺陷或诱导皮肤重建。我们首次通过简单有效的技术展示了掺有硼硅酸盐生物玻璃（BBG）的海藻酸钠（SA）伤口敷料，可加速伤口愈合。对SA-BBG复合伤口敷料的理化性能、体外和体内性能进行了研究。结果表明SA-BBG复合敷料具有良好的吸水性能。BBG中的硼和硅离子可以保持稳定、持续的释放。最重要的是，SA-BBG复合伤口敷料在大鼠全层皮肤缺损中表现出出色的伤口愈合能力。SA-BBG复合敷料组治疗的伤口在第15天时几乎已经闭合。当海绵中海藻酸钠与生物玻璃的比例为3:1时，伤口愈合效果最好。