To induce bone regeneration efficiently, a properly designed organic-inorganic composite scaffold is necessary and important. Gelatin-hydroxyapatite (HA) composite is a suitable choice for the purpose because it can resemble the chemical composition of natural bone tissue. The gelatin-HA composite can be implanted into bone defects as a hydrogel or cryogel, however, it is interesting to know the effect of their different morphology on inducing osteogenesis in vivo . Herein, HA nanowire (HANW) reinforced photocrosslinkable methacrylated gelatin (GelMA) cryogel and hydrogel are prepared and comparatively investigated by being implanted into rat calvarial defects. The cryogel acts as a kind of sponge with interconnected macropores, allowing cell infiltration, as well as, displaying rapid shape recovery and excellent mechanical stability under cyclic compression loading. Conversely, the hydrogel is rigid and easily crushed during the first compression test, showing no shape re...

中文翻译：

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明胶-羟基磷灰石复合冷冻凝胶有效修复大鼠颅骨缺损。

为了有效地诱导骨再生，设计合理的有机-无机复合支架是必要且重要的。明胶-羟基磷灰石 (HA) 复合材料是该目的的合适选择，因为它可以类似于天然骨组织的化学成分。明胶-HA 复合材料可以作为水凝胶或冷冻凝胶植入骨缺损中，然而，有趣的是了解它们不同形态对体内诱导成骨的影响。在此，制备了 HA 纳米线 (HANW) 增强的可光交联甲基丙烯酸化明胶 (GelMA) 冷冻凝胶和水凝胶，并通过植入大鼠颅骨缺损中进行了比较研究。冷冻凝胶充当一种具有相互连接的大孔的海绵，允许细胞浸润，以及，在循环压缩载荷下显示出快速的形状恢复和出色的机械稳定性。相反，水凝胶是刚性的，在第一次压缩测试中很容易被压碎，显示没有形状重新...