The Wnt signaling pathway appears to activate intracellular signaling transduction in embryonic development, cell migration, hematopoiesis, and several diseases. Wnt signaling is basically recognized as a canonical β-catenin-dependent signaling pathway. However, in recent years, generally three Wnt-mediated pathways have been investigated, which operate independently of β-catenin and include calcium/calmodulin-dependent kinase II and protein kinase C, planar cell polarity, and a third one recruits hetrotrimeric GTP-binding proteins to stimulate phospholipase C and phosphodiesterase. We provide an overview of the noncanonical Wnt signaling pathway and then will focus on canonical Wnt signaling components, Wnt ligands, agonists, and antagonist. This review will also discuss β-catenin, both cytoplasmic and nuclear mechanisms, through signaling transduction, and, as a consequence, we have briefly highlighted potential implications of Wnt/β-catenin in some cancers.

中文翻译：

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Wnt 网络：途径和多功能组件的简要回顾。

Wnt 信号通路似乎在胚胎发育、细胞迁移、造血和几种疾病中激活细胞内信号转导。Wnt 信号基本上被认为是一种典型的 β-catenin 依赖性信号通路。然而，近年来，通常研究了三种 Wnt 介导的途径，它们独立于 β-catenin 运作，包括钙/钙调蛋白依赖性激酶 II 和蛋白激酶 C、平面细胞极性，第三种途径招募异三聚体 GTP 结合蛋白来刺激磷脂酶 C 和磷酸二酯酶。我们概述了非经典 Wnt 信号通路，然后将重点介绍经典 Wnt 信号组件、Wnt 配体、激动剂和拮抗剂。本综述还将讨论 β-连环蛋白，包括细胞质和核机制，