Environmental cues are essential in defining tumour malignancy, by promoting tumour initiation, progression and metastatic spreading. Stromal cells may metabolically cooperate or compete with cancer cells, playing a mandatory role in defining cancer metabolic plasticity, potentially dictating the final tumour outcome. Assessing shared nutrients between different tumoural or stromal compartments is essential to understand the impact of environmental nutrients on the metabolic plasticity of tumours. Here, we review analytical and computational approaches for studying the tumour metabolic microenvironment, the destiny of nutrients shared among tumour and stromal populations, as well as the molecular modules of these metabolic relationships.

中文翻译：

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肿瘤微环境中的代谢细胞通讯：模型，方法和观点。

通过提示肿瘤的发生，进展和转移扩散，环境提示对于确定肿瘤的恶性至关重要。基质细胞可能在代谢上与癌细胞竞争或竞争，在定义癌症的代谢可塑性中起着必不可少的作用，可能决定了最终的肿瘤结局。评估不同肿瘤或间质区室之间共享的营养对于了解环境营养对肿瘤代谢可塑性的影响至关重要。在这里，我们审查分析和计算方法，以研究肿瘤代谢微环境，肿瘤和基质人群之间共享的营养的命运，以及这些代谢关系的分子模块。