Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural advances in endoplasmic reticulum targeting fidelity, and in the redistribution of mistargeted substrates are discussed. We further review new discoveries in quality control at the inner nuclear membrane in the context of orphaned subunits. We consider developments in our understanding of cargo selection for endoplasmic reticulum export. Conflicting data on quality control by cargo receptor proteins are discussed and we look to important future questions for the field.

中文翻译：

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内质网中的蛋白质质量控​​制。

早期分泌途径中错误折叠和错误靶向的蛋白质会给细胞带来重大风险。多样化和综合的质量控制途径网络保护细胞免受这些威胁。我们专注于发现有助于这种保护网络的新机制。讨论了内质网靶向保真度以及错误靶向底物重新分布方面的生化和结构进展。我们进一步回顾了孤立亚单位背景下内核膜质量控制的新发现。我们考虑了我们对内质网出口货物选择的理解的发展。讨论了关于货物受体蛋白质量控制的相互矛盾的数据，我们期待着该领域未来的重要问题。