Immune-targeted approaches are rapidly changing the therapeutic landscape for cancer. In spite of that, most patients show resistance or acquire resistance to these therapies. Increasing work describing the tumor microenvironment (TME) has highlighted this space as one of the key determinants in tumor immune response and immunotherapeutic success. Frequently overlooked within this space, cancer-associated fibroblasts (CAFs) within the TME have surfaced as an important dictator of the tumor immune response. Herein, we review recent advances in defining the role of CAF-immune cell interactions in solid tumors and prospects for targeting stroma to overcome resistance to immunotherapy.

中文翻译：

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癌症相关成纤维细胞：肿瘤免疫和免疫治疗的关键决定因素。

免疫靶向方法正在迅速改变癌症的治疗前景。尽管如此，大多数患者对这些疗法表现出抗药性或获得抗药性。越来越多的描述肿瘤微环境 (TME) 的工作强调了这一空间是肿瘤免疫反应和免疫治疗成功的关键决定因素之一。TME 内的癌症相关成纤维细胞 (CAF) 在这一领域经常被忽视，它已成为肿瘤免疫反应的重要决定因素。在此，我们回顾了在确定 CAF 免疫细胞相互作用在实体瘤中的作用方面的最新进展，以及靶向基质以克服免疫治疗耐药性的前景。