Metabolomics is a rapidly expanding technology that finds increasing application in a variety of fields, form metabolic disorders to cancer, from nutrition and wellness to design and optimization of cell factories. The integration of metabolic snapshots with metabolic fluxes, physiological readouts, metabolic models, and knowledge-informed Artificial Intelligence tools, is required to obtain a system-level understanding of metabolism. The emerging power of multi-omic approaches and the development of integrated experimental and computational tools, able to dissect metabolic features at cellular and subcellular resolution, provide unprecedented opportunities for understanding design principles of metabolic (dis)regulation and for the development of precision therapies in multifactorial diseases, such as cancer and neurodegenerative diseases.

中文翻译：

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系统代谢组学：从代谢组学快照到设计原则。

代谢组学是一种快速发展的技术，在各种领域中都有越来越多的应用，从营养和保健到细胞工厂的设计和优化，从癌症到新陈代谢紊乱都有。需要将代谢快照与代谢通量，生理读数，代谢模型和知情的人工智能工具集成在一起，以获得对代谢的系统级理解。多组学方法的新兴力量以及集成的实验和计算工具的开发，能够以细胞和亚细胞分辨率解析代谢特征，为理解代谢（失调）调节的设计原理以及开发精确疗法提供了前所未有的机会。多因素疾病，例如癌症和神经退行性疾病。