Vitamin D (VD) has the function of antibacteria and protect intestinal mucosa. Diacylglycerol has the property of dissolving VD, anti‐bacterial, and antioxidant effects. The purpose of this study was to explore the potentially synergistic effects of diacylglycerol and VD in ameliorating dextran sodium sulfate‐induced colitis in rats. A 2 × 3 factorial design was used in this experiment, consisting of two levels of VD (2.5 and 5 μg/day) crossed with three levels of duck oil diacylglycerol (0.5, 1, and 2 mL/day). The experiment lasted for 2 weeks. Compared with the colitis group, the physiological indexes were altered in colitis rats treated with diacylglycerol and VD, the concentrations of the pro‐inflammatory indices were significantly reduced, the antioxidant enzyme activities were significantly increased, the diversity of caecal microflora was significantly increased. Besides, the expression of PPARγ was up‐regulated while the expression of NF‐κBp65 was downregulated. The changes of all those measures were toward those in the Healthy Control, and the mostly appropriate combination was 1 mL/day of diacylglycerol plus 2.5 μg/day VD.

中文翻译：

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二酰基甘油和维生素 D 在改善右旋糖酐硫酸钠诱导的大鼠结肠炎中的协同作用。

维生素D（VD）具有抗菌和保护肠黏膜的作用。二酰基甘油具有溶解VD、抗菌、抗氧化作用。本研究的目的是探索甘油二酯和 VD 在改善右旋糖酐硫酸钠诱导的大鼠结肠炎中的潜在协同作用。本实验使用 2 × 3 因子设计，由两个水平的 VD（2.5 和 5 μg/天）与三个水平的鸭油二酰甘油（0.5、1 和 2 mL/天）交叉组成。实验持续了2周。与结肠炎组相比，甘油二酯和维生素D治疗结肠炎大鼠的生理指标发生改变，促炎指标浓度显着降低，抗氧化酶活性显着升高，盲肠菌群的多样性显着增加。此外，PPARγ的表达上调而NF-κBp65的表达下调。所有这些措施的变化都朝着健康对照中的变化，最合适的组合是 1 mL/天的甘油二酯加 2.5 μg/天的 VD。