Magnetic drug delivery as a potential method to treat diseases such as cancer tumors has attracted the attention of many researchers. One of the problems in conventional and ineffective therapies is the spread of drug in the circulatory system. The method of magnetic drug delivery aims at directing the drug to the localized area of disease by using a magnetic field. Considering the effects of parameters such as non-Newtonian viscosity, oscillatory input, motion and the presence of atherosclerosis, the present study examines the magnetic drug delivery, which is under the influence of magnetic field, in a 90-degree bent in three situations of without atherosclerosis, a moderate atherosclerosis of 45% and severe atherosclerosis of 75% in two states of fixed vessel and moving vessel arising from the expansion and contraction of the heart. The magnetic field is in the range of [Formula: see text] T, and the diameter of magnetic particles varies from 1 to 6 μm. The comparison of particle absorption percentage for different atherosclerosis revealed that the presence of atherosclerosis increases the value of particle absorption percentage. The results of comparison between fixed vessel and moving vessel indicate that the percentage of particle absorption is higher when the vessel is moving. In the presence of magnetic field, the maximum value of absorption percentage is 76.93% for the moving vessel with 75% atherosclerosis and the particles with the diameter of 6 μm and this value is equal to 75.65% when the vessel is considered fixed. Regardless of the size of particle, this value is approximately 15.8% and 3% for the moving vessel and the fixed vessel, respectively, when no magnetic force is applied to the vessel.

中文翻译：

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通过在 90 度弯曲的容器中使用磁场进行药物递送的数值研究：3D 模拟。

磁性药物递送作为治疗癌症等疾病的潜在方法引起了许多研究人员的关注。传统和无效疗法的问题之一是药物在循环系统中的扩散。磁性药物递送方法旨在通过使用磁场将药物引导至疾病的局部区域。考虑到非牛顿粘度、振荡输入、运动和动脉粥样硬化等参数的影响，本研究考察了在磁场影响下的 90 度弯曲三种情况下的磁性药物递送无动脉粥样硬化，心脏扩张和收缩引起的固定血管和运动血管两种状态下，中度动脉粥样硬化45%，重度动脉粥样硬化75%。磁场在[公式：见正文]T的范围内，磁性粒子的直径在1到6μm之间变化。不同动脉粥样硬化的颗粒吸收百分比的比较表明，动脉粥样硬化的存在增加了颗粒吸收百分比的值。固定容器和移动容器的比较结果表明，容器移动时颗粒吸收的百分比较高。在有磁场的情况下，动脉粥样硬化75%的运动血管和直径为6 μm的颗粒的吸收百分比最大值为76.93%，当血管被认为是固定的时，该值等于75.65%。无论颗粒大小如何，对于移动容器和固定容器，该值分别约为 15.8% 和 3%，