The relation between freezing of gait in Parkinson's disease and levodopa is complex. Here, we describe a new phenotype of freezing of gait, namely levodopa-induced freezing of gait with a biphasic pattern. Our observation supports the idea that freezing of gait might emerge because of a mismatch between cognitive/limbic loops and motor loops involved in gait control. Moreover, it underscores the importance of assessing the influence of dopaminergic medication in daily clinical practice, including objective assessment in all three dopaminergic states. The possibility of biphasic freezing will only emerge after such a comprehensive evaluation, and will have immediate therapeutic consequences.

中文翻译：

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双相左旋多巴诱导的帕金森病步态冻结。

帕金森病步态冻结与左旋多巴之间的关系是复杂的。在这里，我们描述了一种新的步态冻结表型，即左旋多巴诱导的双相步态冻结。我们的观察支持以下观点，即步态冻结可能是由于步态控制中涉及的认知/边缘环和运动环之间的不匹配而出现的。此外，它还强调了在日常临床实践中评估多巴胺能药物影响的重要性，包括对所有三种多巴胺能状态的客观评估。双相冷冻的可能性只有在经过如此全面的评估后才会出现，并会立即产生治疗效果。