This short report describes the relationships between concentrations of ceramides (CER), diacylglycerols (DAG), triacylglycerols (TAG) in very low‐density lipoproteins (VLDL) particles, and hepatic lipid accumulation. VLDL particles were isolated from male subjects (n = 12, mean ± SD, age 42.1 ± 5.4 years, BMI 37.4 ± 4.1 kg/m², ALT 45 ± 21 U/L) and apolipoprotein B100 (apoB100), VLDL‐TAG, ‐CER, and ‐DAG quantified. The contents of all three lipids were highly correlated with VLDL particle number (r ≥ 0.768, p ≤ 0.003). The molar quantity of VLDL‐TAG was 3× that of DAG and 137× that of CER (14,053 ± 5714, 5004 ± 2714, and 105 ± 49 mol/mol apoB100, respectively). Reduced VLDL‐CER concentrations were associated with both higher insulin levels (r = −0.645, p = 0.024) and intrahepatic‐TAG (r = −0.670, p = 0.017). In fatty liver, the secretion of hepatic TAG, CER, and DAG may be suppressed and contribute to intrahepatic lipotoxicity. The mechanisms by which hepatic‐CER and ‐DAG synthesis and assembly into VLDL is coordinately controlled with TAG will be important in understanding the emerging role of elevated CER contributing to cardiometabolic disease.

中文翻译：

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胰岛素抵抗男性中极低密度脂蛋白神经酰胺，-二酰基甘油和-三酰基甘油之间的关系。

这份简短的报告描述了极低密度脂蛋白（VLDL）颗粒中神经酰胺（CER），二酰基甘油（DAG），三酰基甘油（TAG）的浓度与肝脂质蓄积之间的关系。从男性受试者中分离出VLDL颗粒（n = 12，平均±SD，年龄42.1±5.4岁，BMI 37.4±4.1 kg / m ²，ALT 45±21 U / L）和载脂蛋白B100（apoB100），VLDL-TAG， -CER和-DAG量化。所有三种脂质的内容与VLDL粒子数（高度相关ř ≥0.768，p  ≤0.003）。VLDL-TAG的摩尔量是DAG的3倍，是CER的137倍（分别是apoB100的14,053±5714、5004±2714和105±49 mol / mol）。VLDL-CER浓度降低与较高的胰岛素水平有关（r= -0.645，p = 0.024）和肝内TAG（r = -0.670，p = 0.017）。在脂肪肝中，肝TAG，CER和DAG的分泌可能受到抑制，并有助于肝内脂毒性。TAG可以协调控制肝CER和DAG合成和组装成VLDL的机制，对于理解CER升高对心脏代谢疾病的新兴作用至关重要。