To study the expression of aldo-keto reductase 1 member B1 (AKR1B1) in gastric carcinoma (GC), the correlation between AKR1B1 and the clinicopathological characteristics of GC patients, and provide reference for the diagnosis and prognosis of GC patients. One hundred thirty-six patients with GC were collected, and the expression level of AKR1B1 in GC and adjacent tissues was detected by immunohistochemistry assays. The clinicopathological features and prognosis of GC patients were collected to analyze the relationship with AKR1B1 expression. The positive expression of AKR1B1 in GC tissues was significantly higher than that of adjacent nontumor tissues. The difference of AKR1B1 expression between GC tissues and paired adjacent nontumor tissues was statistically significant (p < 0.001). AKR1B1 was closely related to tumor size, regional lymph node (N), metastases (M), and tumor–node–metastasis (TNM) stage (p < 0.05). The overall survival of patients with low expression of AKR1B1 was significantly better than that of patients with high expression of AKR1B1 by Kaplan–Meier survival analysis (p < 0.001). AKR1B1 plays an important role in the occurrence and development of GC, and it has a certain reference value for the prognosis of GC patients.

中文翻译：

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醛固酮还原酶1成员B1在胃癌中的表达及其临床意义。

研究醛固酮还原酶1成员B1（AKR1B1）在胃癌（GC）中的表达及其与胃癌临床病理特征的相关性，为胃癌的诊断和预后提供参考。收集136例胃癌患者，采用免疫组织化学方法检测其在胃癌及癌旁组织中AKR1B1的表达水平。收集GC患者的临床病理特征和预后，分析其与AKR1B1表达的关系。AKR1B1在GC组织中的阳性表达明显高于相邻的非肿瘤组织。GC组织和配对的相邻非肿瘤组织之间的AKR1B1表达差异具有统计学意义（p <0.001）。AKR1B1与肿瘤大小，局部淋巴结转移（N），转移（M）和肿瘤淋巴结转移（TNM）阶段密切相关（p  <0.05）。通过Kaplan–Meier生存分析，AKR1B1低表达患者的总体生存率明显高于AKR1B1高表达患者的总体生存率（p  <0.001）。AKR1B1在GC的发生发展中起重要作用，对GC患者的预后具有一定的参考价值。