The objective of this study was to determine the minimum inhibitory concentrations (MICs) of nine antimicrobials (enrofloxacin, ciprofloxacin, norfloxacin, gentamicin, spectinomycin, oxytetracycline, tylosin, florfenicol, and tiamulin) against 24 Mycoplasma ovipneumoniae isolates obtained from sheep and goats and to compare the resulting antimicrobial profiles. Enrofloxacin and ciprofloxacin had the lowest MIC₅₀ values (<0.03 μg/mL) and MIC₉₀ values (0.25 μg/mL) for all tested isolates. The highest MIC₅₀ value (2 μg/mL) was obtained for florfenicol, while oxytetracycline and tylosin exhibited the highest MIC₉₀ values (16 μg/mL). The MIC values for all fluoroquinolones and oxytetracycline were significantly lower for sheep isolates. Sheep isolates were considerably more susceptible to norfloxacin and tylosin than were goat isolates. This study demonstrated differences in antimicrobial susceptibilities between sheep and goat isolates, revealing M. ovipneumoniae in goat isolates to be less susceptible. The results suggest a possible link between antimicrobial profiles of M. ovipneumoniae isolates and their host ruminant species.

中文翻译：

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绵羊和绵羊支原体肺炎支原体分离物的抗菌敏感性。

本研究的目的是确定九个抗微生物剂（恩诺沙星，环丙沙星，诺氟沙星，庆大霉素，大观霉素，土霉素，泰乐菌素，氟苯尼考和硫姆林）对24的最小抑菌浓度（MIC）绵羊肺炎支原体分离株从绵羊和山羊，向所得比较所得的抗菌谱。对于所有测试的分离物，恩诺沙星和环丙沙星的最低MIC ₅₀值（<0.03μg/ mL）和最低MIC ₉₀值（0.25μg/ mL）。氟苯尼考的最高MIC ₅₀值为2μg/ mL，土霉素和泰乐菌素的MIC ₉₀最高。值（16μg/ mL）。绵羊分离株的所有氟喹诺酮和土霉素的MIC值均显着降低。与山羊分离株相比，绵羊分离株对诺氟沙星和泰乐菌素的敏感性要高得多。这项研究表明，绵羊和山羊分离株之间的抗菌药敏性存在差异，这表明山羊分离株中的猪肺炎支原体较不易感染。结果表明，猪肺炎支原体分离物的抗菌谱与其宿主反刍动物之间可能存在联系。