INTRODUCTION Results conflict on the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk, despite wide-ranging investigations. This meta-analysis examines whether the XRCC2 rs3218536 polymorphism is associated with ovarian cancer risk. MATERIAL AND METHODS Eligible case-control studies were searched in PubMed. We therefore performed a meta-analysis of 5,802 ovarian cancer cases and 9,390 controls from 7 articles published. The strength of association between XRCC2 rs3218536 polymorphism and ovarian cancer susceptibility was calculated using pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). RESULTS No statistically significant associations between XRCC2 rs3218536 polymorphism and ovarian cancer risk were found in any genetic models. However, a significant relationship with ovarian cancer risk was discovered when the high quality studies were pooled in the meta-analysis (AA vs. GG: OR = 0.59, 95% CI: 0.37-0.94, p = 0.03; GA vs. GG: OR = 0.87, 95% CI: 0.78-0.96, p = 0.009; GA + AA vs. GG: OR = 0.85, 95% CI: 0.77-0.94, p = 0.003; AA vs. GG + GA: OR = 0.60, 95% CI: 0.38-0.95, p = 0.03). CONCLUSIONS This meta-analysis shows that the XRCC2 rs3218536 polymorphism was associated with ovarian cancer risk overall for high quality studies. Non-Caucasian groups and high quality studies should be further studied.

中文翻译：

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XRCC2 rs3218536多态性与卵巢癌风险相关性分析。

引言 尽管进行了广泛的调查，但 XRCC2 rs3218536 多态性与卵巢癌风险之间的关联的结果存在冲突。这项荟萃分析检查了 XRCC2 rs3218536 多态性是否与卵巢癌风险相关。材料和方法 在 PubMed 中搜索了符合条件的病例对照研究。因此，我们对已发表的 7 篇文章中的 5,802 例卵巢癌病例和 9,390 例对照进行了荟萃分析。XRCC2 rs3218536 多态性与卵巢癌易感性之间的关联强度使用合并优势比 (ORs) 和相应的 95% 置信区间 (CIs) 计算。结果 在任​​何遗传模型中均未发现 XRCC2 rs3218536 多态性与卵巢癌风险之间存在统计学意义的关联。然而，在荟萃分析中汇总高质量研究时发现与卵巢癌风险显着相关（AA vs. GG：OR = 0.59，95% CI：0.37-0.94，p = 0.03；GA vs. GG：OR = 0.87, 95% CI: 0.78-0.96, p = 0.009; GA + AA vs. GG: OR = 0.85, 95% CI: 0.77-0.94, p = 0.003; AA vs. GG + GA: OR = 0.60, 95% CI：0.38-0.95，p = 0.03）。结论这项荟萃分析表明，XRCC2 rs3218536 多态性与高质量研究的总体卵巢癌风险相关。非白种人群体和高质量的研究应该进一步研究。03)。结论这项荟萃分析表明，XRCC2 rs3218536 多态性与高质量研究的总体卵巢癌风险相关。非白种人群体和高质量的研究应该进一步研究。03)。结论这项荟萃分析表明，XRCC2 rs3218536 多态性与高质量研究的总体卵巢癌风险相关。非白种人群体和高质量的研究应该进一步研究。