INTRODUCTION Telomeres play an important role in maintaining chromosomal integrity. Functional loss of telomeres increases the risk of cancer by causing genomic instability. Telomere length abnormalities have been reported in several precancerous lesions. There is no study that evaluates telomere length in Billroth II distal gastrectomy, which is known as a risk factor for gastric stump carcinogenesis, in the literature. The aim of this study was to assess the relationship between the telomere length of residual gastric mucosal samples, peripheral blood lymphocytes, and other clinicopathological parameters of patients who had undergone Billroth II distal gastrectomy. MATERIAL AND METHODS There were two groups: a control group (n = 15) and a patient group (n = 15). In all cases, upper gastrointestinal endoscopy was performed, and biopsies were taken during endoscopy. Telomere lengths were measured by qRT-PCR. RESULTS It was observed that the lengths of the telomeres were shortened as the time of postoperative period increased in the patient group (r = -0.126) (p > 0.05). Also, the lengths of the telomeres were shortened in chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia. CONCLUSIONS The telomere length was shortened as the time of postoperative period increased in the patient group. The telomeres were also shorter in chronic inflammation, neutrophil activity, intestinal metaplasia, and glandular atrophy, in all of the study groups. Telomere length abnormalities in gastric stump carcinogenesis process may be a guide for early diagnosis and treatment.

中文翻译：

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接受 Billroth II 远端胃切除术的患者胃粘膜样本和外周血淋巴细胞的端粒长度。

引言 端粒在维持染色体完整性方面发挥着重要作用。端粒功能丧失会导致基因组不稳定，从而增加患癌症的风险。在几个癌前病变中报告了端粒长度异常。文献中没有研究评估 Billroth II 远端胃切除术中的端粒长度，这被认为是胃残端癌变的危险因素。本研究的目的是评估残留胃黏膜样本的端粒长度、外周血淋巴细胞和接受 Billroth II 远端胃切除术的患者的其他临床病理参数之间的关系。材料和方法 有两组：对照组（n = 15）和患者组（n = 15）。所有病例均进行了上消化道内窥镜检查，并在内窥镜检查期间进行活检。通过qRT-PCR测量端粒长度。结果观察到患者组随着术后时间的增加端粒长度缩短（r=-0.126）（p>0.05）。此外，端粒的长度在慢性炎症、中性粒细胞活动、腺体萎缩和肠化生中缩短。结论 患者组患者端粒长度随着术后时间的增加而缩短。在所有研究组中，慢性炎症、中性粒细胞活性、肠化生和腺体萎缩的端粒也较短。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。结果观察到患者组随着术后时间的增加端粒长度缩短（r=-0.126）（p>0.05）。此外，端粒的长度在慢性炎症、中性粒细胞活动、腺体萎缩和肠化生中缩短。结论 患者组患者端粒长度随着术后时间的增加而缩短。在所有研究组中，慢性炎症、中性粒细胞活性、肠化生和腺体萎缩的端粒也较短。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。结果观察到患者组随着术后时间的增加端粒长度缩短（r=-0.126）（p>0.05）。此外，端粒的长度在慢性炎症、中性粒细胞活动、腺体萎缩和肠化生中缩短。结论 患者组患者端粒长度随着术后时间的增加而缩短。在所有研究组中，慢性炎症、中性粒细胞活性、肠化生和腺体萎缩的端粒也较短。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。在慢性炎症、中性粒细胞活动、腺体萎缩和肠化生中，端粒的长度缩短。结论 患者组患者端粒长度随着术后时间的增加而缩短。在所有研究组中，慢性炎症、中性粒细胞活性、肠化生和腺体萎缩的端粒也较短。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。在慢性炎症、中性粒细胞活动、腺体萎缩和肠化生中，端粒的长度缩短。结论 患者组患者端粒长度随着术后时间的增加而缩短。在所有研究组中，慢性炎症、中性粒细胞活性、肠化生和腺体萎缩的端粒也较短。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。所有研究组均出现肠化生和腺体萎缩。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。所有研究组均出现肠化生和腺体萎缩。胃残端癌变过程中的端粒长度异常可能是早期诊断和治疗的指南。