Objective. To determine the prevalence of suicidal concerns (SC) in a large multiple sclerosis (MS) patient group and to assess the major determinants that are implicated in their occurrence. Methods. A total of 349 patients were included in the study. They completed a survey about their demographic characteristics, psycho-socio-economic data, and disease-related information. Their disability level was assessed using the Expanded Disability Status Scale (EDSS) based on the neurological examination performed by the same doctor for every patient and the SC were documented with the Beck Depression Inventory-II questionnaire. Results. The study included 112 men and 237 women, with a mean age around 42 years old. Suicidal thoughts were more frequent in men, while suicidal intentions in women. Positive correlations were found between SC and depression, EDSS, total number of relapses, disease duration, and level of education. From the EDSS functional scores, only the pyramidal score and the cerebellar score presented a significant correlation with SC. None of the patients with clinically isolated syndrome had SC. The type of disease-modifying therapy, marital and occupational status, and the presence of children did not influence the presence of SC. Conclusions. The prevalence of SC is higher in patients with MS compared to the general population. Their occurrence is mostly influenced by the disease itself (duration, relapses, acquired disability) and also by depression and lack of education.

中文翻译：

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罗马尼亚多发性硬化患者队列中自杀意念的主要决定因素。

客观。确定大型多发性硬化症 (MS) 患者群体中自杀问题 (SC) 的发生率，并评估与其发生有关的主要决定因素。方法。共有 349 名患者被纳入研究。他们完成了一项关于其人口特征、心理社会经济数据和疾病相关信息的调查。他们的残疾水平是使用扩展残疾状态量表（EDSS）评估的，该量表基于同一位医生对每位患者进行的神经系统检查，并使用贝克抑郁量表-II 问卷记录 SC。结果. 该研究包括 112 名男性和 237 名女性，平均年龄约为 42 岁。男性有自杀念头，女性有自杀倾向。SC与抑郁症、EDSS、复发总数、疾病持续时间和教育水平之间存在正相关。从 EDSS 功能评分来看，只有锥体评分和小脑评分与 SC 显着相关。临床孤立综合征患者均未发生 SC。疾病缓解治疗的类型、婚姻和职业状况以及儿童的存在不影响 SC 的存在。结论. 与一般人群相比，MS 患者的 SC 患病率更高。它们的发生主要受疾病本身（持续时间、复发、获得性残疾）以及抑郁症和缺乏教育的影响。