With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments. In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.

中文翻译：

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脑源性神经营养因子及其在中风合并症中的潜在治疗作用。

随着全球人口老龄化的增加，中风合并症已成为严重的健康威胁和人类社会的巨大经济负担。当前的治疗策略主要集中于在中风发作后的急性期保护神经元免受细胞毒性损害，这不仅是缓解中风症状的困难方法，而且对患者及时接受有效治疗提出了挑战。脑源性神经营养因子（BDNF）是成人脑中最丰富的神经营养蛋白，具有显着的修复脑损伤的能力。近期有希望的临床前成果使BDNF成为新型卒中治疗方法开发中的热门后期靶标。在这篇评论中