Complications of Type 1 diabetes (T1DM) remain prevalent due to suboptimal glycaemic control despite advances in analogue insulin, its delivery and technological advances in glucose monitoring. Intensive insulin therapy is associated with hypoglycaemia and weight gain. Non–insulin-dependent glucose lowering strategies may provide a strategy in improving glycaemic control without hypoglycaemia and weight gain.

中文翻译：

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1型DM治疗中除胰岛素外的非胰岛素疗法。

尽管血糖控制不佳，但由于模拟胰岛素的改进，其递送和血糖监测技术的进步，导致1型糖尿病（T1DM）的并发症仍然普遍存在。胰岛素强化治疗与血糖过低和体重增加有关。非胰岛素依赖性降糖策略可能为改善血糖控制提供了一种策略，而不会引起低血糖和体重增加。