Low serum vitamin D levels are very common in human immunodeficiency virus (HIV)-infected patients. In our cross-sectional study, we investigated the association between 25-hydroxyvitamin D (25(OH)D) levels and serum inflammation markers [C-reactive protein (CRP), white blood cells (WBC), D-dimers, platelet count (PLT)] in 148 HIV-infected patients on combined antiretroviral therapy [28 on tenofovir alafenamide (TAF)] and 40 healthy controls. The controls were significantly older (56.6 ± 19.1 years for HIV(−) vs. 45.1 ± 11.8 years for HIV(+); p = .001) and more females were observed in this group (65% for HIV(−) vs. 16.7% for HIV(+); p = .001). The vitamin D serum level was comparable in the two studied groups (74.2 ± 35.9 nmol/L for HIV(+) vs. 78.0 ± 27.6 nnmol/L for HIV(−), p = .545). In HIV-infected group, a significant positive correlation between CD4+ cell percentage and vitamin D level was observed (r = 0.17; p = .036). Furthermore, the significant negative correlation between vitamin D level and CD8+ cell percentage, PLT, CRP, and D-dimers was seen. In univariate analysis, only TAF use and AIDS status was associated with vitamin D level deficiency. No other antiretroviral (ARV) drug nor gender or smoking had influence on vitamin D serum level. In multivariate analysis, only AIDS status and CRP level were correlated with vitamin D level (slope estimate = 11.6 and p = .032 and slope estimate = −0.83 and p = .002; respectively). In summary, we report that low vitamin D level may be associated with high CRP level in HIV-infected patients on suppressive antiretroviral therapy, especially in AIDS phase. More larger studies are required to assess our observation concerning TAF use and vitamin D level in HIV-positive patients.

中文翻译：

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HIV感染患者接受抗逆转录病毒疗法抑制性低维生素D的危险因素。

低血清维生素D水平在感染人类免疫缺陷病毒（HIV）的患者中非常普遍。在我们的横断面研究中，我们调查了25-羟基维生素D（25（OH）D）水平与血清​​炎症标志物[C反应蛋白（CRP），白细胞（WBC），D-二聚体，血小板计数]之间的关联（PLT）]在148名接受抗逆转录病毒联合疗法治疗的HIV感染患者中[28在Tenofovir alafenamide（TAF）上接受治疗]和40名健康对照。对照组年龄较大（HIV（-）为56.6±19.1岁，HIV（+）为45.1±11.8岁；p  = .001），并且该组中的女性更多（HIV（-）为65％。 HIV（+）为16.7％；p  = 0.001）。在两个研究组中，维生素D的血清水平相当（HIV（+）为74.2±35.9 nmol / L，而HIV（-）为78.0±27.6 nnmol / L，p  = .545）。在HIV感染组中，观察到CD4 +细胞百分比与维生素D水平呈显着正相关（r  = 0.17；p  = .036）。此外，还发现维生素D水平与CD8 +细胞百分比，PLT，CRP和D-二聚体之间显着负相关。在单变量分析中，只有使用TAF和艾滋病状态与维生素D水平缺乏有关。没有其他抗逆转录病毒（ARV）药物，性别或吸烟对维生素D血清水平没有影响。在多变量分析中，仅艾滋病状态和CRP水平与维生素D水平相关（斜率估计值= 11.6和p  = .032，斜率估计值= -0.83和p = .002; 分别）。总之，我们报告说，在抗逆转录病毒疗法的抑制下，尤其是在AIDS期，HIV感染患者的维生素D水平低可能与CRP水平高有关。需要更大规模的研究来评估我们对HIV阳性患者使用TAF和维生素D水平的观察。