Abstract Pseudomonas aeruginosa and Serratia marcescens are prominent members belonging to the group of ESKAPE pathogens responsible for Urinary Tract Infections (UTI) and nosocomial infections. Both the pathogens regulate several virulence factors, including biofilm formation through quorum sensing (QS), an intercellular communication mechanism. The present study describes the anti-biofilm and QS quenching effect of thiazolinyl-picolinamide based palladium(II) complexes against P. aeruginosa and S. marcescens. Palladium(II) complexes showed quorum sensing inhibitory potential in inhibiting swarming motility behaviour, pyocyanin production and other QS mediated virulence factors in both P. aeruginosa and S. marcescens. In addition, the establishment of biofilms was prevented on palladium (II) coated catheters. Overall, the present study demonstrates that thiazolinyl-picolinamide based palladium (II) complexes will be a promising strategy to combat device-mediated UTI infections.

中文翻译：

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新型噻唑啉基-吡啶甲酰胺基钯 (II) 复合物浸渍导尿管可抑制尿路病原体的毒力并分解其生物膜

摘要 铜绿假单胞菌和粘质沙雷氏菌是导致尿路感染 (UTI) 和医院感染的 ESKAPE 病原体组的重要成员。这两种病原体都调节几种毒力因子，包括通过群体感应 (QS) 形成生物膜，这是一种细胞间通讯机制。本研究描述了基于噻唑啉基-吡啶甲酰胺的钯 (II) 复合物对铜绿假单胞菌和粘质链球菌的抗生物膜和 QS 淬灭作用。Palladium (II) 复合物显示出群体感应抑制潜力，可抑制 P. aeruginosa 和 S. marcescens 中的蜂群运动行为、绿脓素产生和其他 QS 介导的毒力因子。此外，防止在钯 (II) 涂层导管上形成生物膜。全面的，