AMPK is one of the main regulators of energy homeostasis in the cell, achieving this role in part by upregulating autophagy in times of nutrient deprivation. Previous reports have described several AMPK substrates involved in autophagy regulation; however, there are still undiscovered AMPK downstream effectors that could play an important role in autophagy. In a new article, Dohmen et al. discovered that the CCNY-CDK16 complex is a novel AMPK substrate involved in autophagy activation.

中文翻译：

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旧的自噬调节剂的新技巧：通过CCNY（cyclin Y）-CDK16依赖AMPK的自噬调节。

AMPK是细胞能量稳态的主要调节剂之一，部分通过在营养剥夺时上调自噬来实现这一功能。先前的报道已经描述了几种参与自噬调节的AMPK底物。然而，仍然有尚未发现的AMPK下游效应子在自噬中起重要作用。在新文章中，Dohmen等人。发现CCNY-CDK16复合物是一种涉及自噬激活的新型AMPK底物。