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New Strategies for Safe Cancer Therapy Using Electrospun Nanofibers: A Short Review.
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-07-31 , DOI: 10.2174/1389557520666200513120924
Mohsen Doostmohammadi 1 , Hamid Forootanfar 2 , Seeram Ramakrishna 3
Affiliation  

Electrospun nanofibers regarding their special features, including high drug loading capacity, high surface to volume area, flexibility, and ease of production and operation, are of great interest for being used in tissue engineering, and drug delivery approaches. In this context, several studies have been done for the production of biodegradable and biocompatible scaffolds containing different anticancer agents for fighting with solid tumors. Surprisingly, these scaffolds are able to deliver different combinations of drugs and agents, such as nanoparticles and release them in a time dependent manner. Here in this review, we summarize the principles of electrospinning and their uses in entrapment of drugs and anti-proliferative agents suitable for cancer therapy. The latest studies performed on treating cancer using electrospinning are mentioned and their advantages and disadvantages over conventional treatment methods are discussed.



中文翻译:

使用电纺纳米纤维进行癌症安全治疗的新策略:简短回顾。

关于电纺纳米纤维的特殊功能,包括高载药量,高表面积/体积面积,柔韧性以及易于生产和操作,在组织工程和药物输送方法中引起了极大的兴趣。在这种情况下,已经进行了一些研究来生产包含不同的抗癌剂以对抗实体瘤的可生物降解和生物相容的支架。令人惊讶地,这些支架能够递送药物和试剂(例如纳米颗粒)的不同组合并以时间依赖性方式释放它们。在本文中,我们总结了静电纺丝的原理及其在诱捕适合癌症治疗的药物和抗增殖剂中的用途。

更新日期:2020-08-21
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