Background: Several studies have linked acetaminophen exposure to the risk of allergic rhinitis, with controversial results. Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was conducted up to December 1, 2019. We included observational studies that examined the association between acetaminophen exposure and the risk of allergic rhinitis. Two reviewers independently extracted data and assessed study quality. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. Results: Eighteen studies with 870,492 participants were included. Analysis showed that acetaminophen exposure was associated with an increased risk of allergic rhinitis (OR: 1.54, 95% CI: 1.41–1.69). Also, early exposure and exposure in the past year to acetaminophen was positively associated with risk of allergic rhinitis (OR: 1.34, 95% CI: 1.21–1.49 and OR: 1.74, 95% CI: 1.48–2.04, respectively). The risk of allergic rhinitis was greater for people who had acetaminophen exposure once per month over the past year (OR: 1.90, 95% CI: 1.60–2.26) compared to once per year (OR: 1.28, 95% CI: 1.11–1.48). Conclusion: With our meta-analysis, we provide the evidence that exposure to acetaminophen is associated with an increased risk of allergic rhinitis. In addition, acetaminophen exposure in early life and acetaminophen exposure in the past year are positively associated with the risk of allergic rhinitis. Future research is needed to evaluate whether the association is causal.
Int Arch Allergy Immunol

中文翻译：

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对乙酰氨基酚暴露与变应性鼻炎相关的累积证据。

背景：几项研究将对乙酰氨基酚暴露与过敏性鼻炎的风险联系起来，结果存在争议。方法：截至2019年12月1日，对PubMed，Embase，Cochrane图书馆和Web of Science进行了系统搜索。我们纳入了观察性研究，研究了对乙酰氨基酚暴露与变应性鼻炎风险之间的关系。两名审稿人独立提取数据并评估研究质量。使用随机效应荟萃分析计算汇总比值比（OR）和95％置信区间（CI）。结果：包括18,870,492名参与者的研究。分析表明，对乙酰氨基酚暴露与变应性鼻炎的风险增加相关（OR：1.54，95％CI：1.41-1.69）。而且，早期暴露和过去一年对乙酰氨基酚暴露与变应性鼻炎的风险呈正相关（OR：1.34，95％CI：1.21–1.49和OR：1.74，95％CI：1.48–2.04）。在过去的一年中，每月对乙酰氨基酚暴露一次的人（OR：1.90，95％CI：1.60–2.26）患过敏性鼻炎的风险高于每年一次（OR：1.28，95％CI：1.11–1.48） ）。结论：通过我们的荟萃分析，我们提供了证据表明暴露于对乙酰氨基酚会增加变应性鼻炎的风险。此外，早期的对乙酰氨基酚暴露和过去一年的对乙酰氨基酚暴露与变应性鼻炎的风险呈正相关。需要进一步的研究来评估关联是否为因果关系。
Int Arch过敏免疫