Recent studies on the mechanisms that link metabolic changes with stem cell fate have deepened our understanding of how specific metabolic pathways can regulate various stem cell functions during the development of an organism. Although it was originally thought to be merely a consequence of the specific cell state, metabolism is currently known to play a critical role in regulating the self-renewal capacity, differentiation potential, and quiescence of stem cells. Many studies in recent years have revealed that metabolic pathways regulate various stem cell behaviors (e.g., selfrenewal, migration, and differentiation) by modulating energy production through glycolysis or oxidative phosphorylation and by regulating the generation of metabolites, which can modulate multiple signaling pathways. Therefore, a more comprehensive understanding of stem cell metabolism could allow us to establish optimal culture conditions and differentiation methods that would increase stem cell expansion and function for cell-based therapies. However, little is known about how metabolic pathways regulate various stem cell functions. In this context, we review the current advances in metabolic research that have revealed functional roles for mitochondrial oxidative phosphorylation, anaerobic glycolysis, and oxidative stress during the self-renewal, differentiation and aging of various adult stem cell types. These approaches could provide novel strategies for the development of metabolic or pharmacological therapies to promote the regenerative potential of stem cells and subsequently promote their therapeutic utility.

关于将代谢变化与干细胞命运联系起来的机制的最新研究，加深了我们对特定代谢途径如何在生物体发育过程中调节各种干细胞功能的理解。尽管最初认为它只是特定细胞状态的结果，但目前已知新陈代谢在调节干细胞的自我更新能力，分化潜能和静止中起关键作用。近年来的许多研究表明，代谢途径通过糖酵解或氧化磷酸化来调节能量产生，并通过调节代谢产物的生成来调节多种干细胞的行为（例如自我更新，迁移和分化），而代谢产物可以调节多种信号传导途径。因此，对干细胞代谢的更全面的了解可以使我们建立最佳的培养条件和分化方法，从而增加干细胞的扩增和细胞疗法的功能。然而，关于代谢途径如何调节各种干细胞功能的了解甚少。在这种情况下，我们回顾了代谢研究的最新进展，这些进展揭示了各种成人干细胞类型的自我更新，分化和衰老过程中，线粒体氧化磷酸化，厌氧糖酵解和氧化应激的功能性作用。这些方法可以为代谢或药物疗法的发展提供新的策略，以促进干细胞的再生潜力并随后促进其治疗用途。我们回顾了代谢研究的最新进展，这些进展揭示了各种成体干细胞类型的自我更新，分化和衰老过程中线粒体氧化磷酸化，厌氧糖酵解和氧化应激的功能作用。这些方法可以为代谢或药物疗法的发展提供新的策略，以促进干细胞的再生潜力并随后促进其治疗用途。我们回顾了代谢研究的最新进展，这些进展揭示了在各种成体干细胞类型的自我更新，分化和衰老过程中，线粒体氧化磷酸化，厌氧糖酵解和氧化应激的功能性作用。这些方法可以为代谢或药物疗法的发展提供新的策略，以促进干细胞的再生潜力并随后促进其治疗用途。