Effects of Nano-Zinc on Immune Function in Qianbei-Pockmarked Goats.,Biological Trace Element Research

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Effects of Nano-Zinc on Immune Function in Qianbei-Pockmarked Goats.
Biological Trace Element Research ( IF 3.9 ) Pub Date : 2020-05-11 , DOI: 10.1007/s12011-020-02182-z
Chunjie Song ₁ , Shangquan Gan ₂ , Jian He ₁ , Xiaoyun Shen _{1,

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Affiliation

Qianbei-pockmarked goats are vital to the production system of western China. This study aimed to determine the influence of nano-zinc on immune function in zinc-deprived goats. We analyzed the mineral concentrations in soil, forage, and animal tissue. Blood parameters and immune indexes were also determined. Results showed that the zinc concentrations in soil and forage from affected area were significantly lower than those in control area (P < 0.01). Zinc contents in tissues (blood and hair) from affected Qianbei-pockmarked goats were also significantly lower than those in healthy animals (P < 0.01). Levels of hemoglobin, erythrocyte count, and packed cell volume from affected animals were markedly lower than those in healthy animals (P < 0.01). Levels of lactate dehydrogenase, alkaline phosphatase, superoxide dismutase, glutathione peroxide, catalase, and total antioxidant capacity in serum in affected animals were significantly lower, and aspartate aminotransferase, alanine transaminase, malondialdehyde in serum were significantly higher than those in healthy goats (P < 0.01). The contents of immunoglobulin A, immunoglobulin M, immunoglobulin G, interleukin-2, interleukin 6, and interleukin-1β from affected animals were significantly lower than those in healthy animals (P < 0.01). The affected Qianbei-pockmarked goats were treated orally with nano-zinc, the concentration of zinc in blood significantly increased, and serum immune indexes greatly returned to that within the healthy range. It was concluded that nano-zinc could not only markedly increase the zinc content in blood of zinc-deprived goats but also much improve the immune function.

更新日期：2020-05-11

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