The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

中文翻译：

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围产期饮食会影响白血病小鼠模型的健康和生存。

当前研究的目的是确定围产期母体饮食对后代健康和生存的作用。使用AKR / J小鼠（据称易患白血病），在雌性与SD喂养的情况下，以标准饮食（SD），高蔗糖饮食，西方饮食或卡路里限制（CR）维持雌性男性。体重，妊娠率，产仔数和产仔存活率被用作成功怀孕和幼犬健康的标志。数据表明，母亲饮食对产仔数，幼仔早期存活和幼仔体重有显着影响。随着幼犬的成熟，它们各自母体饮食的构成是成年代谢健康和生存的预测指标。总体，