Type 2 diabetes (T2D) is usually accompanied with a number of complications including neuropathologic changes. Not only peripheral neuropathies are frequently accompanied with diabetes, but also the structural and functional integrity of brain could be impaired in diabetic patients [1]. The risk of Parkinson’s disease (PD) is seven folds higher in diabetic patients than in normal people [2]. Clinical and epidemiological studies have also shown that T2D is significantly associated with PD [3]. However, the underling molecular links between PD and diabetes are still unclear.

中文翻译：

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KKAy糖尿病小鼠大脑中的蛋白质组改变暗示着糖尿病和帕金森氏病之间的潜在分子联系。

2型糖尿病（T2D）通常伴有许多并发症，包括神经病理学改变。糖尿病患者不仅会伴有周围神经病变，而且还会损害大脑的结构和功能完整性[1]。糖尿病患者的帕金森氏病（PD）风险比正常人高7倍[2]。临床和流行病学研究还表明，T2D与PD显着相关[3]。然而，PD与糖尿病之间的潜在分子联系仍然不清楚。