INTRODUCTION Anisakiasis is a zoonosis of parasitic origin whose diffusion seems to be continuously increasing. OBJECTIVE The aim of this study was to evaluate the benefits of a fish-free diet in patients allergic to Anisakis simplex as well as underlining the importance of awareness and prevention. Furthermore, we aimed to investigate the critical issues related to the spread of anisakiasis in relation to eating habits. METHODS Patients were assessed by means of skin prick tests (SPTs) and targeted laboratory testing, with an 18-month-long fish-free diet being recommended in cases of severe sensitization. The degree of awareness about anisakiasis was evaluated from interviews. Patients were subjected to follow-up visits after 18 months. RESULTS A total of 70 cases of sensitization to A. simplex were evaluated. The Interview answers highlighted a general state of misinformation among patients and healthy subjects along with a remarkable underestimation of anisakiasis-related risks. An overall lack of care regarding eating habits and diet plans also emerged. In 21 patients affected by severe sensitization, clinical and laboratory evaluations were repeated after 18 months of the subjects being on a fish-free diet. There was a remarkable improvement in serum IgE levels and clinical symptoms. CONCLUSION Data analysis proved the need to implement new and more effective awareness-raising and prevention campaigns in order to reduce the incidence of anisakiasis. It is crucial to establish an adequate diet therapy for sensitized patients. Evaluation of cytokine patterns suggests how a polyphenol-rich regime can activate regulatory T cell function and possibly reduce the allergic and inflammatory components of the disease.

中文翻译：

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Anisakiasis：在过敏患者中预防的重要性和饮食疗法的作用。

引言Anisakiasis是一种寄生虫源性人畜共患病，其扩散似乎在不断增加。目的本研究的目的是评估无鱼饮食对过敏性单瓣茴香的患者的益处，并强调认识和预防的重要性。此外，我们旨在调查与食用习惯相关的茴香病传播的关键问题。方法通过皮肤点刺试验（SPT）和有针对性的实验室检查对患者进行评估，严重过敏者建议采用18个月长的无鱼饮食。通过访谈评估对麻醉病的认识程度。患者在18个月后接受随访。结果共评估了70例对单纯曲霉致敏的病例。访谈的答案强调了患者和健康受试者的错误信息的普遍状况，以及对茴香病相关风险的低估。还出现了对饮食习惯和饮食计划缺乏全面照顾的情况。在21名受到严重致敏影响的患者中，在受试者接受无鱼饮食18个月后，重复了临床和实验室评估。血清IgE水平和临床症状明显改善。结论数据分析证明，有必要开展新的和更有效的提高认识和预防运动，以减少肛门异位症的发生。为致敏的患者建立适当的饮食疗法至关重要。