There is an urgent need to design a tissue-engineered vascular graft that exhibits good biocompatibility and sufficient mechanical strength to repair and facilitate regeneration of defective vascular tissue. It is generally accepted that multi-layer stents can be used to simulate the structure and function of natural blood vessels. Here, we developed a new three-layer tubular graft that is rolled from a single Poly(L-lactide-co-caprolactone) electrospun membrane. We used a new electrospinning technique to place three different structures on a single electrospun membrane such that the stent is comprised of three different layers. The inner layer is dense and suitable for endothelial cell growth, the middle layer is a parallel loose structure suitable for smooth muscle cell growth, and the outer layer is a parallel structure with sparse alternating texture suitable for both smooth muscle cell growth and structural support. The vascular stent has good tensile strength. At the same ...

中文翻译：

---

三层血管支架制备新方法：三级电纺膜制备仿生三层血管支架的初步研究[J].

迫切需要设计一种具有良好生物相容性和足够机械强度的组织工程血管移植物，以修复和促进有缺陷的血管组织的再生。人们普遍认为，多层支架可用于模拟天然血管的结构和功能。在这里，我们开发了一种新的三层管状移植物，它由单个聚（L-丙交酯-共-己内酯）电纺膜卷起。我们使用一种新的静电纺丝技术将三种不同的结构放置在单个静电纺丝膜上，这样支架就由三个不同的层组成。内层致密，适合内皮细胞生长，中层为平行疏松结构，适合平滑肌细胞生长，外层为平行结构，质地稀疏交替，适合平滑肌细胞生长和结构支撑。血管支架具有良好的抗拉强度。同时...