This study was designed to explore the impact of Lycium barbarum polysaccharide (LBP) on inflammation and gut microbiota in mice with allergic asthma. Mice were divided into four groups: control group, OVA (ovalbumin) group, Con+LBP group, OVA+LBP group. After 28 days of LBP intervention, mice were euthanized and associated indications were investigated. Histopathological examination demonstrated that LBP reduced lung injury. The results of our current study provide evidence that supplementation with LBP in asthmatic mice decreases TNF, IL-4, IL-6, MCP-1, and IL-17A in plasma and bronchoalveolar lavage fluid (BALF). Sequencing and analysis of gut microbiota indicated that compared with the OVA group, Lactobacillus and Bifidobacterium were increased, but Firmicutes, Actinobacteria, Alistipes, and Clostridiales were decreased in the OVA+LBP group. We also found that gut microbiota were related to inflammation-related factors. Therefore, we speculate that LBP may improve allergic asthma by altering gut microbiota and inhibiting inflammation in mice.

中文翻译：

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从枸杞叶中提取的枸杞多糖通过减少炎症反应和调节肠道菌群来改善小鼠哮喘。

这项研究旨在探讨枸杞多糖（LBP）对过敏性哮喘小鼠炎症和肠道菌群的影响。将小鼠分为四组：对照组，OVA（卵清蛋白）组，Con + LBP组，OVA + LBP组。LBP干预28天后，对小鼠实施安乐死并研究了相关适应症。组织病理学检查表明，LBP减轻了肺损伤。我们当前研究的结果提供了证据，证明哮喘小鼠补充LBP可降低TNF，IL-4，IL-6，MCP-1和IL-17A在血浆和支气管肺泡灌洗液（BALF）中。肠道菌群的测序和分析表明，与OVA组相比，OVA + LBP组的乳酸杆菌和双歧杆菌有所增加，但硬菌，放线菌，阿利斯贝氏菌和梭状芽胞菌减少。我们还发现肠道菌群与炎症相关因素有关。因此，我们推测LBP可以通过改变肠道菌群和抑制小鼠炎症来改善过敏性哮喘。