Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and diagnostic tool commonly known as biomarkers. Biomarkers play important roles in the diagnosis of various chronic diseases, including cancer. Neurodegenerative disorders, including Parkinson's, Alzheimer's, Huntington's, prion, and multiple sclerosis, are well characterized by neuronal deterioration, resulting in precise modifications of neuronal proteins. Nowadays, the diagnosis of neurological disorders is based on proteins or biomarkers. These biomarkers may be found in the cerebrospinal fluid, blood, serum, plasma, saliva, or urine sample. Early diagnosis is urgently needed to prevent further damage. For early diagnosis, identifying the changes in novel protein levels and their functions under the disease conditions is necessary. These can be used as specific proteomic biomarkers for diseases, and they can be possibly identified using neuroproteomics. Neuroproteomics is an emerging tool to corroborate disease-associated protein profiles. It also gives an idea about how these proteins interact with other proteins and undergo post-translational modifications. Neuroproteomics is based on bioinformatics, which provides functional characteristics and advances in technology such as mass spectroscopy, and can help in the discovery of various disease-specific biomarkers. This review gives a complete idea about the types of biomarkers, sources of biomarkers, and techniques involved in the discovery of biomarkers for early diagnosis of neurodegenerative diseases.

蛋白质结构和功能的变化，蛋白质-蛋白质相互作用的改变以及体内蛋白质浓度的显着差异可能在指示临床症状出现之前指示异常的病理学证据方面起重要作用，并充当关键的检测和诊断工具俗称生物标志物。生物标志物在包括癌症在内的各种慢性疾病的诊断中起着重要作用。神经退行性疾病，包括帕金森氏症，阿尔茨海默氏症，亨廷顿氏症，病毒和多发性硬化症，特征在于神经元退化，导致神经元蛋白质的精确修饰。如今，神经系统疾病的诊断基于蛋白质或生物标志物。这些生物标志物可能存在于脑脊液，血液，血清，血浆，唾液或尿液样本。迫切需要早期诊断以防止进一步的损害。为了进行早期诊断，必须确定疾病条件下新型蛋白质水平及其功能的变化。这些可以用作疾病的特定蛋白质组生物标志物，并且可以使用神经蛋白质组学进行鉴定。神经蛋白质组学是一种证实疾病相关蛋白质谱的新兴工具。它还给出了有关这些蛋白质如何与其他蛋白质相互作用并进行翻译后修饰的想法。神经蛋白质组学基于生物信息学，它提供了功能特征和诸如质谱等技术的进步，并且可以帮助发现各种特定疾病的生物标记。这篇评论提供了有关生物标记物类型，生物标记物来源，