Both skeletal muscle and adipose tissue are considered as endocrine organs due to their ability to produce and secrete several bioactive peptides (e.g. myokines and adipokines). Those bioactive molecules are well known for their capacity to influence whole-body homeostasis and alterations in their production/secretion are contributing to the development of various metabolic disorders. While it is well accepted that changes in the composition and functionality of the gut microbiota are associated with the onset of several pathological disorders (e.g. obesity, diabetes, and cancer), its contribution to the regulation of the myokine-adipokine profile and function remains largely unknown. This review will focus on myokines and adipokines with a special interest on their interaction with the gut microbiota.

中文翻译：

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肠道微生物群和肌肉因子-脂肪因子功能的调节。

骨骼肌和脂肪组织都被认为是内分泌器官，因为它们能够产生和分泌多种生物活性肽（例如肌肉因子和脂肪因子）。这些生物活性分子以其影响全身稳态的能力而闻名，其产生/分泌的改变导致各种代谢紊乱的发展。虽然人们普遍认为肠道微生物群的组成和功能的变化与多种病理疾病（例如肥胖、糖尿病和癌症）的发生有关，但它对肌肉因子-脂肪因子谱和功能的调节作用仍然很大未知。本综述将重点关注肌肉因子和脂肪因子，特别关注它们与肠道微生物群的相互作用。