As investigators decipher the underlining mechanisms of Staphylococcus aureus pathogenesis, it is becoming apparent that perturbations in central metabolism alter virulence factor production and infection outcomes. It is also evident that S. aureus has the ability to metabolically adapt to improve colonization and overcome challenges imparted by the immune system. Altered metabolite pools modify virulence factor production suggesting that proper functioning of a core metabolic network is necessary for successful niche colonization and pathogenesis. Herein we discuss four examples of transcriptional regulators that monitor metabolic status. These regulatory systems sense perturbations in the metabolic network and respond by altering the transcription of genes utilized for central metabolism, energy generation and pathogenesis.

中文翻译：

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金黄色葡萄球菌毒力因子产生的代谢控制。

随着研究人员破译金黄色葡萄球菌发病机理的重要机制，越来越明显的是，中枢代谢紊乱会改变毒力因子的产生和感染的结果。同样明显的是，金黄色葡萄球菌具有代谢适应能力，以改善定植并克服免疫系统赋予的挑战。改变的代谢物库会改变毒力因子的产生，这表明核心代谢网络的正常运行对于成功的利基定植和发病机理是必要的。在这里，我们讨论监视代谢状态的转录调节子的四个例子。这些调节系统感知代谢网络中的扰动，并通过改变用于中枢代谢，能量产生和发病机理的基因的转录来作出反应。