This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.

中文翻译：

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Cammalleri 姐妹的表型特征，一个特别长寿的例子。

本文展示了两个特殊兄弟姐妹的人口统计学、临床、回忆、认知和功能数据以及生化、遗传和表观遗传参数：Diega（超级百岁老人）和 Filippa（半超级百岁老人）Cammalleri。这项研究的目的是为半超级百岁老人和超级百岁老人所代表的极端表型提供新的见解。关于超级百岁老人的不同研究已经发表，但据我们所知，这是唯一关于两姐妹的，并且从表型的角度来看是最详细的。我们的研究结果同意超级百岁老人对年龄相关疾病的相对抵抗力越来越强的建议，​​接近成功解决急性死亡原因的功能性人类储备的极限。更有趣的是，我们的数据同意，