In this study, we aimed to systematically review the literature to evaluate the effects of magnesium (Mg) supplementation on blood pressure (BP) and obesity measure among patients with type 2 diabetes mellitus (T2DM). Major electronic databases of Web of Science, the Cochrane library, PubMed, and Scopus were searched completely from the inception until 15 October 2019 to identify randomized clinical trials (RCTs) pertaining to the topic of interest. All outcomes were pooled using a random-effects model and expressed as weighted mean differences (WMD) with 95% confidential intervals (CI). Heterogeneity, sensitivity analysis, and publication bias were also assessed using standard methods. The pooled analysis of five RCTs showed that Mg supplementation did not affect body weight (WMD: − 0.01 kg, 95% CI: − 0.36 to 0.33), BMI (WMD: − 0.07, 95% CI: − 0.18 to 0.04), and waist circumference (WMD: 0.12, 95% CI: − 1.24 to 1.48) in T2DM patients compared to the control groups of the patients who received placebo. However, pooling seven RCTs together showed significant reduction of systolic blood pressure (WMD: − 5.78 mmHg, 95% CI: − 11.37 to − 0.19) and diastolic blood pressure (WMD: − 2.50 mmHg, 95% CI: − 4.58 to − 0.41) in T2DM patients. Furthermore, subgroup analysis by dose of intervention, intervention duration, and type of intervention suggested that Mg supplementation for > 12 weeks, in doses higher than 300 mg/day or inorganic forms, could significantly decrease both systolic and diastolic BP in T2DM patients. Based on the findings, Mg supplementation has beneficial effects on BP in type 2 diabetes patients independent of body weight status. However, further investigations are needed to provide more reliable evidences.

在这项研究中，我们旨在系统地回顾文献，以评估补充镁（Mg）对2型糖尿病（T2DM）患者的血压（BP）和肥胖测量的影响。从开始到2019年10月15日，对Web of Science，Cochrane图书馆，PubMed和Scopus的主要电子数据库进行了全面搜索，以识别与感兴趣的主题有关的随机临床试验（RCT）。所有结果均采用随机效应模型汇总，并以95％机密间隔（CI）表示为加权平均差异（WMD）。还使用标准方法评估了异质性，敏感性分析和出版物偏倚。五个RCT的汇总分析显示，添加Mg不会影响体重（WMD：− 0.01 kg，95％CI：− 0.36至0.33），BMI（WMD：− 0.07，95％CI：− 0。与接受安慰剂的对照组相比，T2DM患者的腰围（WMD：0.12，95％CI：− 1.24至1.48）和腰围（WMD：0.12，95％CI：− 1.24至1.48）。然而，将七个RCT汇集在一起​​显示收缩压（WMD：− 5.78 mmHg，95％CI：− 11.37至− 0.19）和舒张压（WMD：− 2.50 mmHg，95％CI：− 4.58至− 0.41）显着降低）在T2DM患者中。此外，按干预剂量，干预时间和干预类型进行的亚组分析表明，以高于300 mg /天的剂量或无机形式补充Mg> 12周，可以显着降低T2DM患者的收缩压和舒张压。根据这些发现，补充镁对2型糖尿病患者的血压具有有益的作用，而与体重状况无关。然而，