Acute administration of methylphenidate differentially affects cortical processing of emotional facial expressions in attention-deficit hyperactivity disorder children as studied by functional near-infrared spectroscopy.,Neurophotonics

当前位置： X-MOL 学术 › Neurophotonics › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Acute administration of methylphenidate differentially affects cortical processing of emotional facial expressions in attention-deficit hyperactivity disorder children as studied by functional near-infrared spectroscopy.
Neurophotonics ( IF 4.8 ) Pub Date : 2020-05-06 , DOI: 10.1117/1.nph.7.2.025003
Megumi Kobayashi _{1,

2} , Takahiro Ikeda _{2,

3} , Tatsuya Tokuda _{2,

4} , Yukifumi Monden _{2,

3,

4,

5} , Masako Nagashima _{2,

3} , Sakae G Mizushima _{2,

4} , Takeshi Inoue _{2,

6} , Keiichi Shimamura _{2,

6} , Yuta Ujiie _{2,

7} , Akari Arakawa _{2,

6} , Chie Kuroiwa _{2,

6} , Mayuko Ishijima ₈ , Yuki Kishimoto ₄ , So Kanazawa _{2,

9} , Takanori Yamagata ₃ , Masami K Yamaguchi _{2,

10} , Ryoichi Sakuta _{2,

6} , Ippeita Dan _{2,

4}

Affiliation

Institute for Developmental Research, Aichi Developmental Disability Center, Department of Functioning and Disability, Kagiya-cho, Kasugai, Aichi, Japan.
RISTEX (Research Institute of Science and Technology for Society) Group, Kasuga, Bunkyo, Tokyo, Japan.
Jichi Medical University, Department of Pediatrics, Yakushiji, Shimotsuke, Tochigi, Japan.
Chuo University, Applied Cognitive Neuroscience Laboratory, Kasuga, Bunkyo, Tokyo, Japan.
International University of Health and Welfare, Department of Pediatrics, Iguchi, Nasushiobara, Tochigi, Japan.
Dokkyo Medical University, Child Development and Psychosomatic Medicine Center, Minamikoshigaya, Koshigaya, Saitama, Japan.
Chuo University, Research and Development Initiative, Kasuga, Bunkyo, Tokyo, Japan.
Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Japan Women's University, Department of Psychology, Nishi-Ikuta, Tama, Kawasaki, Kanagawa, Japan.
Chuo University, Department of Psychology, Higashinakano, Hachioji, Tokyo, Japan.

Significance: It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation patterns in response to facial expressions. However, little is known about neural mechanisms underlying the impaired recognition of facial expressions in school-aged children with ADHD and the effects of acute medication on their processing of facial expressions. Aim: We aimed to investigate the possibility that acute administration of methylphenidate (MPH) affects processing of facial expressions in ADHD children. Approach: We measured the hemodynamic changes in the bilateral temporo-occipital areas of ADHD children observing the happy and angry facial expressions before and 1.5 h after MPH or placebo administration in a randomized, double-blind, placebo-controlled, crossover design study. Results: We found that, regardless of medication, happy expressions induced increased oxyhemoglobin (oxy-Hb) responses in the right inferior occipital region but not in the superior temporal region. For angry expressions, oxy-Hb responses increased after MPH administration, but not after placebo administration, in the left inferior occipital area, whereas there was no significant activation before MPH administration. Conclusions: Our results suggest that (1) ADHD children consistently recruit the right inferior occipital regions to process happy expressions and (2) MPH administration to ADHD children enhances cortical activation in the left inferior occipital regions when they process angry expressions.

中文翻译：

通过功能性近红外光谱研究，急性给予哌醋甲酯对注意力缺陷多动障碍儿童情绪面部表情的皮层处理有不同的影响。

意义：据报道，患有注意力缺陷多动障碍（ADHD）的儿童在识别愤怒的面部表情方面存在障碍，但在识别快乐的面部表情方面没有障碍，并且他们对面部表情的反应表现出非典型的皮层激活模式。然而，人们对多动症学龄儿童面部表情识别受损的神经机制以及急性药物对其面部表情处理的影响知之甚少。目的：我们的目的是调查急性服用哌甲酯（MPH）影响 ADHD 儿童面部表情处理的可能性。方法：在一项随机、双盲、安慰剂对照、交叉设计研究中，我们测量了 ADHD 儿童双侧颞枕区的血流动力学变化，观察 MPH 或安慰剂给药前和给药后 1.5 小时的快乐和愤怒的面部表情。结果：我们发现，无论使用何种药物，快乐的表情都会引起右下枕叶区域的氧合血红蛋白 (oxy-Hb) 反应增加，但不会导致颞上区域的反应增加。对于愤怒的表情，左下枕叶区域的氧-Hb 反应在 MPH 给药后增加，但在安慰剂给药后没有增加，而在 MPH 给药前没有明显的激活。结论：我们的结果表明，(1) ADHD 儿童始终调动右下枕叶区域来处理快乐的表情，(2) ADHD 儿童使用 MPH 可以增强他们处理愤怒表情时左下枕叶区域的皮质激活。

更新日期：2020-05-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11