T cells are an important part of the adaptive immune system and play critical roles in the elimination of various pathogens. T cells could differentiate into distinct cellular subsets under different extracellular signals and then play different roles in maintaining host homeostasis and defense. The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family. The mTOR signaling pathway is closely involved in a variety of cell biological processes, including cell growth and cell metabolism, by senses and integrates various environmental cues. Recent studies showed that mTOR including mTORC1 and mTORC2 is closely involved in the development of T cell subpopulations such as Th1, Th2, Th9, Th17, follicular helper T cells (Tfh), and Treg cells through distinctive pathways. We herein mainly focused on the recent progress in understanding the roles of mTOR in regulating the development and differentiation of CD4⁺ T cell subsets.

中文翻译：

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mTOR复合物对CD4 + T细胞亚群的分化和功能的调节作用。

T细胞是适应性免疫系统的重要组成部分，在消除各种病原体中起着至关重要的作用。T细胞可以在不同的细胞外信号下分化为不同的细胞亚群，然后在维持宿主体内稳态和防御中发挥不同的作用。雷帕霉素（mTOR）的机制靶标是保守的胞内丝氨酸/苏氨酸激酶，属于磷酸肌醇3-激酶-（PI3K-）相关的激酶家族。mTOR信号通路通过感知并整合了各种环境线索，紧密参与了各种细胞生物学过程，包括细胞生长和细胞代谢。最近的研究表明，包括mTORC1和mTORC2在内的mTOR与T细胞亚群（如Th1，Th2，Th9，Th17，卵泡辅助性T细胞（Tfh））的发育密切相关，和Treg细胞通过独特的途径 我们在此主要集中于了解mTOR在调节CD4发育和分化中的作用方面的最新进展。⁺ T细胞子集。