Background. Parkinson’s disease (PD) is associated with cognitive decline, progressing from subjective memory complaints (SMC) via mild cognitive impairment (MCI) to dementia. SMC are only measurable by an interview and thus rely on individuals reporting a subjectively perceived worsening of cognitive functioning. Cognitive decline is accompanied by a reduction in quality of life (QoL); however, the extent to which SMC manifest a reduction of QoL remains unclear. Objective. To determine the association between SMC and deterioration of QoL in patients suffering from PD. Methods. A total of 46 cognitively unimpaired PD patients (29 men and 17 women) completed PDQ-39, two assessments to measure SMC (Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and a Self-Assessment questionnaire), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Multiple regression modelling was conducted to investigate the confounding effect of depression and anxiety. Results. The PDQ-39 domain cognitions, but not the PDQ-39 sum score, correlated significantly with the SMC Self-Assessment questionnaire (r = 0.57; ). The conducted regression model indicates a significant confounding effect of depression and anxiety (, R² = 0.55). Conclusion. In our study, SMC is significantly related to a reduction of cognitive QoL. In addition, we observed significant relation to anxiety and depression levels. In contrast to our main hypothesis, we found no association with overall QoL; this lack of association could be due to unstandardized questionnaires and emphasizes the need of validated tools for evaluating SMC.

中文翻译：

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帕金森病主观记忆主诉患者的非运动相关生活质量：与 PDQ-39 的比较。

背景。帕金森氏病 (PD) 与认知能力下降有关，从主观记忆障碍 (SMC) 通过轻度认知障碍 (MCI) 发展为痴呆。SMC 只能通过面谈来衡量，因此依赖于个人报告主观感知到的认知功能恶化。认知衰退伴随着生活质量（QoL）的降低；然而，SMC 降低生活质量的程度仍不清楚。客观。确定 SMC 与 PD 患者生活质量恶化之间的关联。方法. 共有 46 名认知未受损的 PD 患者（29 名男性和 17 名女性）完成了 PDQ-39、两项评估以测量 SMC（老年人认知衰退知情人问卷 (IQCODE) 和自我评估问卷）、贝克抑郁量表 (BDI ) 和贝克焦虑量表 (BAI)。进行多元回归模型以研究抑郁和焦虑的混杂效应。结果。PDQ-39 领域认知，但不是 PDQ-39 总分，与 SMC 自我评估问卷显着相关（r  = 0.57；）。进行的回归模型表明抑郁和焦虑有显着的混杂效应 ( , R ²  = 0.55)。结论 . 在我们的研究中，SMC 与认知生活质量的降低显着相关。此外，我们观察到与焦虑和抑郁水平显着相关。与我们的主要假设相反，我们发现与整体 QoL 没有关联；这种缺乏关联可能是由于调查问卷不标准化，并强调需要经过验证的工具来评估 SMC。