Objective. To screen some RNAs that correlated with colorectal cancer (CRC). Methods. Differentially expressed miRNAs, lncRNAs, and mRNAs between cancer tissues and normal tissues in CRC were identified using data from the Gene Expression Omnibus (GEO) database. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and protein-protein interactions (PPIs) were performed to do the functional enrichment analysis. And a lncRNA-miRNA-mRNA network was constructed which correlated with CRC. RNAs in this network were subjected to analyze the relationship with the patient prognosis. Results. A total of 688, 241, and 103 differentially expressed genes (diff-mRNA), diff-lncRNA, and diff-miRNA were obtained between cancer tissues and normal tissues. A total of 315 edges were obtained in the ceRNA network. lncRNA RP11-108K3.2 and mRNA ONECUT2 correlated with prognosis. Conclusion. The identified RNAs and constructed ceRNA network could provide great sources for the researches of therapy of the CRC. And the lncRNA RP11-108K3.2 and mRNA ONECUT2 may serve as a novel prognostic predictor of CRC.

中文翻译：

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大肠癌中ceRNA共表达网络的构建及分子靶点的筛选。

客观。筛选一些与结直肠癌 (CRC) 相关的 RNA。方法。使用来自基因表达综合 (GEO) 数据库的数据鉴定 CRC 中癌组织和正常组织之间差异表达的 miRNA、lncRNA 和 mRNA。京都基因和基因组百科全书 (KEGG) 通路和蛋白质-蛋白质相互作用 (PPI) 进行了功能富集分析。并构建了与CRC相关的lncRNA-miRNA-mRNA网络。对该网络中的RNA进行分析与患者预后的关系。结果. 在癌组织和正常组织之间共获得了688、241和103个差异表达基因（diff-mRNA）、diff-lncRNA和diff-miRNA。在 ceRNA 网络中总共获得了 315 条边。lncRNA RP11-108K3.2 和 mRNA ONECUT2 与预后相关。结论。鉴定出的RNA和构建的ceRNA网络可为结直肠癌的治疗研究提供重要的资源。lncRNA RP11-108K3.2 和 mRNA ONECUT2 可作为 CRC 的新预后预测因子。