Background. Postoperative lymphocyte to monocyte ratio (post-LMR) change (LMRc) reflects the dynamic change of balance between inflammatory reaction and immune reaction after curative operation. An elevated preoperative LMR (pre-LMR) has been shown to be a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC), but the clinical value of the LMRc remains unknown. Methods. 674 patients in ESCC undergoing curative operation were enrolled in this study. LMRc () was counted on the basis of data within one week before and after operation. The median of LMRc was chosen to be the optimal cut-off value to evaluate the prognostic value of LMRc. Results. Kaplan-Meier curves revealed that was significantly associated with worse overall survival (OS) () and disease-free survival (DFS) (). Multivariate analysis suggested that LMRc could serve as an independent prognostic predictor for both OS (, , 95% CI 0.526-0.898) and DFS (, , 95% CI 0.476-0.859). Conclusions. LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation.

中文翻译：

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术后淋巴细胞与单核细胞比率的变化预示着接受根治性切除的食管鳞状细胞癌患者的不良临床结局。

背景。术后淋巴细胞与单核细胞比值（post-LMR）变化（LMRc）反映了治愈性手术后炎症反应与免疫反应平衡的动态变化。术前 LMR (pre-LMR) 升高已被证明是食管鳞状细胞癌 (ESCC) 患者的预后因素，但 LMRc 的临床价值仍然未知。方法。674 例接受根治性手术的 ESCC 患者入组本研究。LMRc ()根据手术前后一周内的数据统计。选择 LMRc 的中位数作为评估 LMRc 预后价值的最佳截止值。结果。Kaplan-Meier 曲线显示，与较差的总生存期（OS）显着相关（)和无病生存期 (DFS) (）。多变量分析表明 LMRc 可以作为两种 OS 的独立预后预测因子（, , 95% CI 0.526-0.898) 和 DFS (, , 95% CI 0.476-0.859)。结论。LMRc 是一种很有前途的预后预测因子，可用于预测接受根治性手术的 ESCC 患者更差的临床结果。