Objective. Vagus nerve stimulation (VNS) is a nonpharmacologic therapeutic option for patients who have pharmaco-resistant Dravet syndrome (DS). Plentiful efforts have been made for delivering VNS to DS patients, but its effectiveness still requires further verification. We investigated the effectiveness of the VNS treatment of DS patients using brain connectivity analysis with electroencephalography (EEG). Approach. Twenty pharmaco-resistant DS patients were selected to undergo VNS implantation and classified into responder and non-responder groups after 24 months post-VNS. The effect of VNS between 6 months pre- and 6, 12, and 24 months post-VNS in all patients, responders, and non-responders on four different frequency categories of four brain parameters were compared using resting-state EEG. Main results. In alpha and beta bands, all patients showed positive results for characteristic path length (CPL), global efficiency (GE), and transitivity after VNS...

中文翻译：

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迷走神经刺激（VNS）后的Dravet综合征患者的大脑连通性改变：使用脑电图理论分析探讨其有效性。

目的。迷走神经刺激（VNS）是患有药物耐药性Dravet综合征（DS）的患者的非药物治疗选择。为向DS患者提供VNS做出了巨大努力，但其有效性仍需要进一步验证。我们使用脑电图（EEG）进行脑连接分析，研究了VNS治疗DS患者的有效性。方法。选择20名对药物有抗药性的DS患者进行VNS植入，并在VNS后24个月后将其分为反应者和非反应者组。使用静息状态脑电图，比较了VNS之前6个月，6个月，12个月和24个月之后VNS对所有患者，反应者和非反应者对四种脑参数的四种不同频率类别的影响。主要结果。在Alpha和Beta乐队中，