Current Protein & Peptide Science ( IF 1.9 ) Pub Date : 2020-06-30 , DOI: 10.2174/1389203721666200507091952 Ayad A Al-Hamashi 1 , Krystal Diaz 1 , Rong Huang 1
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Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors.
中文翻译：
蛋白质精氨酸甲基转移酶的非组蛋白精氨酸甲基化。
蛋白质精氨酸甲基转移酶 (PRMT) 在 RNA 剪接、DNA 损伤修复、细胞信号传导和分化中发挥着至关重要的作用。精氨酸甲基化是组蛋白和各种非组蛋白的一种重要的转变后修饰，可以激活或抑制基因表达。PRMT 的异常表达与多种异常有关，尤其是癌症。在此，我们回顾了人类 PRMT 所有九个成员的许多非组蛋白蛋白底物，以及 PRMT 介导的非组蛋白精氨酸甲基化如何调节各种疾病。此外，我们重点介绍了几种 PRMT 抑制剂的最新临床研究。
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