Background: Acute intestinal ischemia–reperfusion injury (AIIRI) is a devastating clinical condition relevant to multiple diseases processes, including sepsis, trauma, transplantation, and burns. An AIIRI is a contributor to the development of multiple organ dysfunction syndrome (MODS). Oncostatin M (OSM)/oncostatin M receptor (OSMR) signaling is an unrecognized and novel candidate pathway for the mediation of MODS. In this study, we hypothesized that OSM mediates the injury mechanism of AIIRI leading to MODS.

中文翻译：

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制瘤素 M 在急性肠缺血：再灌注损伤后的生存中发挥关键作用。

背景：急性肠缺血再灌注损伤（AIIRI）是一种破坏性的临床病症，与多种疾病过程相关，包括败血症、外伤、移植和烧伤。AIRII 是导致多器官功能障碍综合征 (MODS) 发展的一个因素。制瘤素 M (OSM)/制瘤素 M 受体 (OSMR) 信号传导是一种未被认识的新型候选途径，用于介导 MODS。在这项研究中，我们假设 OSM 介导了 AIIRI 导致 MODS 的损伤机制。