Background: Many patients with advanced cervical cancer (CC) have a poor prognosis and their mortality rank the first among women with malignant tumors. It's essential to explore the molecular mechanism of CC in clinical practice. Long noncoding RNA maternally expressed gene 3 (MEG3) has been reported to downregulate in CC tissues. However, the underlying mechanism of MEG3 in CC remains poorly elaborated. The current study aimed to explore the potential mechanism of MEG3 inducing endoplasmic reticulum stress (ERs)-mediated apoptosis of CC cells.

中文翻译：

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MEG3通过miR-7-5p/STC1轴通过内质网应激诱导宫颈癌细胞凋亡

背景：许多晚期宫颈癌（CC）患者预后不良，死亡率居恶性肿瘤女性之首。在临床实践中探索CC的分子机制至关重要。据报道，长链非编码 RNA 母源表达基因 3 (MEG3) 在 CC 组织中下调。然而，MEG3 在 CC 中的潜在机制仍未得到很好的阐述。本研究旨在探讨MEG3诱导内质网应激（ERs）介导的CC细胞凋亡的潜在机制。