Blood microparticles are a component of immune modulation in red blood cell transfusion.,European Journal of Immunology

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Blood microparticles are a component of immune modulation in red blood cell transfusion.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-05-07 , DOI: 10.1002/eji.201948481
Marion Klea Pinheiro _{1,

2,

3,

4} , Marie Tamagne _{1,

2,

3,

4} , Rahma Elayeb _{1,

2,

3,

4} , Muriel Andrieu ₅ , France Pirenne _{1,

2,

3,

4} , Benoît Vingert _{1,

2,

3,

4}

Affiliation

Patients may display alloimmunization following transfusion. Microparticles (MPs) released into the blood are present in transfusion products. We show that MPs can modulate the immune system, CD4⁺ T‐cell, and humoral responses, through their concentration, cellular origin and phenotype, and should therefore be considered to reduce the immune impact of transfusion.