当前位置：
X-MOL 学术
›
Biomed. Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells.
Biomedical Materials ( IF 3.9 ) Pub Date : 2020-09-03 , DOI: 10.1088/1748-605x/ab9095 Layla Mosqueira 1 , Breno Rocha Barrioni , Talita Martins , Natália De Melo Ocarino , Rogéria Serakides , Marivalda De Magalhães Pereira
Biomedical Materials ( IF 3.9 ) Pub Date : 2020-09-03 , DOI: 10.1088/1748-605x/ab9095 Layla Mosqueira 1 , Breno Rocha Barrioni , Talita Martins , Natália De Melo Ocarino , Rogéria Serakides , Marivalda De Magalhães Pereira
Affiliation
Osteoporosis is a metabolic disease that affects bone tissue and is highly associated with bone fractures. Typical osteoporosis fracture treatments, such as bisphosphonates and hormone replacement, present important challenges because of their low bioavailability on the site of action. Options to overcome this issue are systems for the local release of therapeutic agents such as bioactive glasses containing therapeutic molecules and ions. These agents are released during the dissolution process, combining the drugs and ion therapeutic effects for osteoporosis treatment. Among the therapeutic agents that can be applied for bone repair are strontium (Sr) ion and phytopharmaceutical icariin, which have shown potential to promote healthy bone marrow stem cells osteogenic differentiation, increase bone formation and prevent bone loss. Submicron Sr-containing bioactive glass mesoporous spheres with sustained ion release capacity were obtained. Icariin was successfully incorporated int...
更新日期：2020-09-05
京公网安备 11010802027423号